"Our results indicate a moderate relation between early teen marijuana use and young adult abuse of other illicit substances; however, this association fades from statistical significance with adjustments for stress and life-course variables. Likewise, our findings show that any causal influence of teen marijuana use on other illicit substance use is contingent upon employment status and is short-term, subsiding entirely by the age of 21. In light of these findings, we urge U.S. drug control policymakers to consider stress and life-course approaches in their pursuit of solutions to the 'drug problem.'"

Source

Van Gundy K, Rebellon CJ. A Life-course Perspective on the "Gateway Hypothesis". J Health Soc Behav. 2010 Sep;51(3):244-59. doi: 10.1177/0022146510378238. PMID: 20943588.