United States

Prevalence Among High School Students in the US of Ever Having Injected a Drug, by Gender

"Nationwide, 1.5% of students had used a needle to inject any illegal drug into their body one or more times during their life (Supplementary Table 129). The prevalence of having ever injected any illegal drug was higher among male (2.0%) than female (0.8%) students; higher among white male (1.4%), black male (2.6%), and Hispanic male (2.1%) than white female (0.5%), black female (1.1%), and Hispanic female (0.9%) students, respectively; and higher among 9th-grade male (2.1%) and 10th-grade male (1.9%) than 9th grade female (0.6%) and 10th-grade female (0.6%) students, respectively.

Current Alcohol Use Among High School Students in the US, by Gender

"Nationwide, 29.8% of students had had at least one drink of alcohol on at least 1 day during the 30 days before the survey (i.e., current alcohol use) (Supplementary Table 98). The prevalence of current alcohol use was higher among female (31.8%) than male (27.6%) students; higher among black female (24.3%) and Hispanic female (35.9%) than black male (16.9%) and Hispanic male (26.8%) students, respectively; and higher among 9th-grade female (22.0%) and 11th-grade female (36.8%) than 9th-grade male (15.3%) and 11th-grade male (31.6%) students, respectively.

Tightened Restrictions on Legal Prescription Hydrocodone Led to Increase in Illegal Sales

"Objective: To examine the effect on the trade in opioids through online illicit markets (“cryptomarkets”) of the US Drug Enforcement Administration’s ruling in 2014 to reschedule hydrocodone combination products.

"Design: Interrupted time series analysis.

"Setting: 31 of the world’s largest cryptomarkets operating from October 2013 to July 2016.

Restrictions On Opioid Prescribing Are Negatively Impacting People With Cancer And Other Serious Illnesses

"A growing number of restrictions on opioid prescribing are already impacting these patient populations."

According to a survey conducted for the American Cancer Society Cancer Action Network and the Patient Quality of Life Coalition:

Patients answering yes to "Has your doctor indicated his or her treatment options for your pain were limited by laws, guidelines, or your insurance coverage?"
Patients Being Treated For Cancer: 48%
Patients Being Treated For Chronic Pain: 40%
Patients Being Treated For Other Serious Illnesses: 56%

CDC Opioid Prescribing Guidelines Are Making It Difficult For Cancer Patients To Obtain Pain Medication

"There has been a significant increase in cancer patients and survivors being unable to access their opioid prescriptions since 2016, when the Centers for Disease Control and Prevention (CDC) finalized opioid prescribing guidelines."

Percent of cancer patients and survivors who report being unable to get opioid prescription pain medication because the pharmacy did not have the particular drug in stock:
December 2016: 16%
May 2018: 41%

Price of Naloxone Has Skyrocketed Since 2006

"We contribute nationally representative evidence to help answer each of these questions, including wholesale pricing data from a proprietary drug sales database spanning January 2006 to February 2017. We find that all formulations of naloxone increased in price since 2006 except for Narcan Nasal Spray. These cumulative increases totaled 2281% for the 0.4 MG single-dose products, 244% for the 2 MG single-dose products, 3797% for the 4 MG multi-dose products, and 469% for the 0.4 MG Evzio auto-injector.

Treatment with Methadone or Buprenorphine Following Nonfatal Overdose Leads to Decreased Mortality

"In the 12 months after a nonfatal overdose, 2040 persons (11%) enrolled in MMT for a median of 5 months (interquartile range, 2 to 9 months), 3022 persons (17%) received buprenorphine for a median of 4 months (interquartile range, 2 to 8 months), and 1099 persons (6%) received naltrexone for a median of 1 month (interquartile range, 1 to 2 months). Among the entire cohort, all-cause mortality was 4.7 deaths (95% CI, 4.4 to 5.0 deaths) per 100 person-years and opioid-related mortality was 2.1 deaths (CI, 1.9 to 2.4 deaths) per 100 person-years.

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