Estimated Lethal Dose of Cannabis

"Tetrahydrocannabinol is a very safe drug. Laboratory animals (rats, mice, dogs, monkeys) can tolerate doses of up to 1000 mg/kg (milligrams per kilogram). This would be equivalent to a 70 kg person swallowing 70 grams of the drug —about 5,000 times more than is required to produce a high. Despite the widespread illicit use of cannabis there are very few if any instances of people dying from an overdose."

Source: 

Iversen, Leslie L., "The Science of Marijuana" Oxford University Press (New York, NY: 2000), p. 178.
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