"Overall, the currently available evidence regarding health outcomes among safer opioid supply clients is generally favorable. Specifically, when reported, most studies found reductions (Brothers et al., 2022; Haines & O'Byrne, 2023a; Lew et al., 2022) or a lack of change (Gomes et al., 2022) in the occurrence of opioid toxicity events, along with a reduction in the frequency of unregulated opioid use among clients of safer opioid supply programs (Bardwell et al., 2023; Giang et al., 2023; Haines & O'Byrne, 2023a; Ivsins et al., 2020, 2022; McNeil et al., 2022). Other health outcomes were also shown to improve among safer opioid supply clients, including increased access to the healthcare system (Gomes et al., 2022; Kolla & Fajber, 2023; Kolla et al., 2021), infectious complications (Gomes et al., 2022), and improvements to clients’ mental health (Gomes et al., 2022; Haines et al., 2022; Kolla & Fajber, 2023; Kolla et al., 2021). Also, participants of qualitative studies expressed that safer opioid supply program participation improved their access to healthcare and other wraparound services (Foreman-Mackey et al., 2022; Giang et al., 2023; Haines & O'Byrne, 2023a; Ivsins et al., 2020; McMurchy & Palmer, 2022), allowing them to address health issues such as HIV and hepatitis C (Kolla et al., 2021). Additionally, safer opioid supply program clients and providers interviewed in qualitative studies expressed that safer opioid supply recipients were afforded a greater sense of stability as clients were less preoccupied with concerns related to drug procurement (Foreman-Mackey et al., 2022; Giang et al., 2023; Haines & O'Byrne, 2023a; Ivsins et al., 2020, 2022; McNeil et al., 2022), or engagement in criminal activity as a means of income generation for drug related purchases (Atkinson, 2023; Haines & O'Byrne, 2023a; Haines et al., 2022; Ivsins et al., 2020, 2021, 2022; Kolla et al., 2021; McNeil et al., 2022)."

Source

Ledlie, S., Garg, R., Cheng, C., Kolla, G., Antoniou, T., Bouck, Z., & Gomes, T. (2024). Prescribed safer opioid supply: A scoping review of the evidence. The International journal on drug policy, 125, 104339. Advance online publication. doi.org/10.1016/j.drugpo.2024.104339