2016 Provisional US Drug Overdose Data via Centers for Disease Control

Total provisional count of drug overdose deaths in the US for the 12-month period ending in December 2016: 71,135.
  Attributed to synthetic opioids (excluding methadone): 19,547
  Attributed to heroin: 15,564
  Attributed to natural and semi-synthetic opioids: 14,550
  Attributed to cocaine: 10,479
  Attributed to psychostimulants with abuse potential: 7,602
  Attributed to methadone: 3,393

Provisional count of drug overdose deaths in the US for the 12-month period ending in December 2015: 51,335.
  Attributed to heroin: 13,051
  Attributed to natural and semi-synthetic opioids: 12,747
  Attributed to synthetic opioids (excluding methadone): 9,610
  Attributed to cocaine: 6,841
  Attributed to psychostimulants with abuse potential: 5,777
  Attributed to methadone: 3,309

Figures above based on data available for analysis on Oct. 1, 2017. The federal Centers for Disease Control compiles and publishes official data on annual causes of death in the United States. Demand for data on drug overdose deaths, and on drug overdoses generally, is so great that the CDC is now making raw data on these subjects available to the public. The data are provisional, not final, so there are several caveats that must be understood before examining the numbers. According to the CDC:
"Provisional counts are often incomplete and causes of death may be pending investigation (see table Notes). Data quality measures, such as percent completeness in overall death reporting and percentage of deaths pending investigation, are included to aid interpretation of provisional data, because both data completeness and the percentage of records pending investigation are related to the accuracy of provisional counts (see Technical Notes). Provisional data are based on available records that meet certain data quality criteria at the time of analysis and may not include all deaths that occurred during a given time period. Therefore, they should not be considered comparable with final data and are subject to change. Reporting of specific drugs and drug classes varies by jurisdiction, and comparisons across selected states should not be made (see Technical Notes)."

Source: 

"Provisional Drug Overdose Death Counts," U.S. Centers for Disease Control, Atlanta, GA, based on data available for analysis on Oct. 1, 2017, last accessed Oct. 19, 2017 at https://www.cdc.gov/nchs/...

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